Mathematical Algorithms – selected publications

• Physiological time-series analysis using approximate entropy and sample entropy.
  Am J Physiol Heart Circ Physiol. 2000 Jun;278(6):H2039-49.
• Sample entropy analysis of neonatal heart rate variability.
  Am J Physiol Regul Integr Comp Physiol. 2002 Sep;283(3):R789-97.
• Accurate estimation of entropy in very short physiological time series: the problem of atrial fibrillation detection in implanted ventricular devices.
  Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H319-25.
• Breath-by-breath analysis of cardiorespiratory interaction for quantifying developmental maturity in premature infants.
  J Appl Physiol. 2012 Mar;112(5):859-67.
• Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias.
  Circ Arrhythm Electrophysiol. 2013 Jun;6(3):555-61.
• Local dynamics of heart rate: detection and prognostic implications.
  Physiol Meas. 2014 Oct;35(10):1929-42.

Predictive Analytics Monitoring – selected publications

• Predictive monitoring for respiratory decompensation leading to urgent unplanned intubation in the neonatal intensive care unit.
  Pediatr Res. 2013 Jan;73(1):104-10.
• Predicting the need for urgent intubation in a surgical/trauma intensive care unit.
  Surgery. 2013 Nov;154(5):1110-6.
• Signatures of Subacute Potentially Catastrophic Illness in the ICU: Model Development and Validation.
  Crit Care Med. 2016 Sep;44(9):1639-48.
• External validation in an intermediate unit of a respiratory decompensation model trained in an intensive care unit.
  Surgery. 2017 Mar;161(3):760-770.
• New-Onset Atrial Fibrillation in the Critically Ill.
  Crit Care Med. 2017 May;45(5):790-797.
• Cardiorespiratory dynamics measured from continuous ECG monitoring improves detection of deterioration in acute care patients: A retrospective cohort study.
  PLoS One. 2017 Aug 3;12(8):e0181448.
• Identifying the low risk patient in surgical intensive and intermediate care units using continuous monitoring.
  Surgery. 2018 Apr;163(4):811-818.
• Dynamic data monitoring improves predictive analytics for failed extubation in the ICU.
  Physiol Meas. 2018 Jul 16;39(7):075005.

Clinical Implementation and Impact – selected publications

• Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: a randomized trial.
  J Pediatr. 2011 Dec;159(6):900-6.e1.
• Computers in White Coats: How to Devise Useful Clinical Decision Support Software.
  Crit Care Med. 2016 Jul;44(7):1449-50.
• Impact of predictive analytics based on continuous cardiorespiratory monitoring in a surgical and trauma intensive care unit.
  J Clin Monit Comput. 2018 Aug 18.
• Advancing Continuous Predictive Analytics Monitoring: Moving from Implementation to Clinical Action in a Learning Health System.
  Crit Care Nurs Clin North Am. 2018 Jun;30(2):273-287.